Transfusion-related acute lung injury (TRALI): a serious adverse event of blood transfusion.

摘要: BACKGROUND AND OBJECTIVES Analyses of fatal transfusion reactions in the UK and USA have shown that transfusion-related acute lung injury (TRALI) is among most common causes reactions. MATERIAL METHODS Review literature was used to analyse TRALI. RESULTS TRALI characterized by respiratory distress non-cardiogenic oedema developing during, or within 6 h of, transfusion. In atypical cases, can become symptomatic much later. must be carefully differentiated from transfusion-associated circulatory overload. its fulminant presentation, clinically indistinguishable syndrome occurring as a result other causes. The severity depends upon susceptibility patient develop more significant reaction an underlying disease process, nature triggers transfused blood components, including granulocyte-binding alloantibodies (immune TRALI) neutrophil-priming substances such biologically active lipids (non-immune TRALI). Immune TRALI, which occurs mainly after fresh-frozen plasma platelet concentrates, rare event (about one incidence per 5000 transfusions) but frequently ( approximately 70%) requires mechanical ventilation (severe not uncommonly (6-9% cases). Non-immune stored erythrocyte seems benign clinical course, with oxygen support sufficient form therapy lower mortality than immune CONCLUSIONS By virtue morbidity mortality, has serious current complications To prevent further antibody-mediated evaluation should include leucocyte antibody testing implicated donors. However, studies are necessary for prevention this complication.