CHAPTER 38 – Perfringolysin O and intermedilysin: mechanisms of pore formation by the cholesterol-dependent cytolysins

摘要: This chapter focuses on aspects of the CDC cytolytic mechanism that have been elucidated in last six years. These studies led to identification several unique features provide a more complete understanding fundamental changes structure assembly pore complex from soluble monomers. Furthermore, discovery activity ILY was restricted human cells has provided an important tool for study membrane recognition by CDCs and role cholesterol mechanism. other also shown while basic poreforming is likely same CDCs, their structures exhibit plasticity enables them adapt facilitate pathogenic bacterial pathogen. In future, continued will reveal additional insights into process formation. It attention now be focused structural allows customized specific purpose pathogen how these pathogens use toxins during disease development.