The MHC E locus in macaques is polymorphic and is conserved between macaques and humans

作者: JonathanE. Boyson , StephenN. McAdam , Awen Gallimore , ThaddeusG. Golos , Xiaomin Liu

DOI: 10.1007/BF00182314

关键词: GeneticsMajor histocompatibility complexAlleleLocus (genetics)BiologyIntronMacaquePeptide bindingMHC class IHuman leukocyte antigen

摘要: Although the functions of molecules encoded by classical MHC class I loci are well defined, no function has been ascribed to non-classical loci. To investigate evolution and conservation loci, we cloned sequenced HLA-E homologues in macaques. We isolated four E locus alleles from five rhesus monkeys two one cynomolgus monkey, which indicated that macaques is polymorphic. also compared rate nucleotide substitution second intron macaque human with exons three. The was significantly higher introns, suggested evolved under selective pressure. Additionally, comparison rates synonymous non-synonymous substitutions peptide binding region versus remainder molecule codons encoding amino acids had conserved humans over 36 million years since last shared a common ancestor.

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