Conservation and Variation in Human and Common Chimpanzee CD94 and NKG2 Genes
作者： Benny P. Shum , Laura R. Flodin , David G. Muir , Raja Rajalingam , Salim I. Khakoo
DOI: 10.4049/JIMMUNOL.168.1.240
关键词:
摘要: To assess polymorphism and variation in human chimpanzee NK complex genes, we determined the coding-region sequences for CD94 NKG2A, C, D, E, F from several (Homo sapiens) donors common chimpanzees (Pan troglodytes). is highly conserved, while NKG2 genes exhibit some polymorphism. For all alternative mRNA splicing variants were frequent among clones obtained by RT-PCR. Alternative acts similarly to produce CD94B variant gene NKG2B NKG2A gene. Whereas single orthologs CD94, NKG2E, NKG2F identified, two paralogs of NKG2C defined. The Pt-NKG2CI encodes a protein similar NKG2C, whereas Pt-NKG2CII translation frame changes near beginning carbohydrate recognition domain, causing premature termination. Analysis panel cell showed that are independently clonally expressed. equally diverged indicating they arose duplication subsequent divergence ancestors. Genomic DNA 80 individuals representing six primate species typed presence NKG2. Each gave distinctive typing patterns, with being most conserved. Seven different genotypes within 48 due differences Pt-NKG2C Pt-NKG2D genes.
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