Presence of corticotropin-releasing factor-like immunoreactivity in human tumors.
作者： Ichiji Wakabayashi , Tetsuta Ihara , Makoto Hattori , Yoji Tonegawa , Tamotsu Shibasaki
DOI: 10.1002/1097-0142(19850301)55:5<995::AID-CNCR2820550513>3.0.CO;2-4
关键词: Biology 、 Adenocarcinoma 、 Internal medicine 、 Pheochromocytoma 、 Thyroid 、 Gastrointestinal tract 、 Medullary carcinoma 、 Thyroid carcinoma 、 Adrenal gland 、 Small-cell carcinoma 、 Endocrinology
摘要: Corticotropin-releasing factor (CRF)-like immunoreactivity was measured by radioimmunoassay in human organs and tumors associated with without ectopic adrenocorticotropic hormone (ACTH) syndrome. It found to be distributed widely the stomach, pancreas, adrenal gland, various (e.g., medullary thyroid carcinoma, small cell carcinoma of lung, pheochromocytoma, adenocarcinoma gastrointestinal tract pancreas) a concentration less than one tenth that hypothalamus. Dilution curves CRF-like tissue extracts paralleled synthetic rat (human) CRF. Sephadex G-50 gel filtration showed major coeluted Results suggest material(s) closely related immunologically CRF is present normal tumor tissues outside central nervous system.
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