MHC class I molecules, structure and function.

摘要: MHC class I molecules (MHC-I) are cell surface recognition elements expressed on virtually all somatic cells. These sample peptides generated within the and signal cell's physiological state to effector cells of immune system, both T lymphocytes natural killer (NK) In addition, structurally related MHC-I, collectively known as MHC-Ib, more specialized and, in some cases, interact with limited subsets lymphoid Using recently determined structure classical MHC-I molecule, H-2Dd, a paradigm for function, we review other MHC-Ib molecules, an emphasis how same basic structural fold is employed by bind specific receptors, exploited stringent molecular interactions. It instructive that have evolved perform number unique distinct functions non-immune recognition.