The Carboxy Terminus of the Ligand Peptide Determines the Stability of the MHC Class I Molecule H-2Kb: A Combined Molecular Dynamics and Experimental Study
作者： Esam Tolba Abualrous , Sunil Kumar Saini , Venkat Raman Ramnarayan , Florin Tudor Ilca , Martin Zacharias
DOI: 10.1371/JOURNAL.PONE.0135421
关键词:
摘要: … To quantify the variation of the binding groove width on a local scale, we divided the binding groove into three regions (region I, which contains the A pocket, region II, in the center of the …
harvard.edu
paperity.org参考文章(73)
R A Mariuzza, D H Margulies, K Natarajan, H Li, MHC class I molecules, structure and function. Reviews in immunogenetics. ,vol. 1, pp. 32- 46 ,(1999)
Peter J. Chefalo, Clifford V. Harding, Processing of Exogenous Antigens for Presentation by Class I MHC Molecules Involves Post-Golgi Peptide Exchange Influenced by Peptide-MHC Complex Stability and Acidic pH Journal of Immunology. ,vol. 167, pp. 1274- 1282 ,(2001) , 10.4049/JIMMUNOL.167.3.1274
Sunil Kumar Saini, Katja Ostermeir, Venkat Raman Ramnarayan, Heiko Schuster, Martin Zacharias, Sebastian Springer, Dipeptides promote folding and peptide binding of MHC class I molecules. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 110, pp. 15383- 15388 ,(2013) , 10.1073/PNAS.1308672110
Heinz Fabian, Hans Huser, Daniele Narzi, Rolf Misselwitz, Bernhard Loll, Andreas Ziegler, Rainer A. Böckmann, Barbara Uchanska-Ziegler, Dieter Naumann, HLA-B27 subtypes differentially associated with disease exhibit conformational differences in solution. Journal of Molecular Biology. ,vol. 376, pp. 798- 810 ,(2008) , 10.1016/J.JMB.2007.12.009
Amit Kumar, Eleonora Cocco, Luigi Atzori, Maria Giovanna Marrosu, Enrico Pieroni, Structural and Dynamical Insights on HLA-DR2 Complexes That Confer Susceptibility to Multiple Sclerosis in Sardinia: A Molecular Dynamics Simulation Study PLoS ONE. ,vol. 8, pp. e59711- ,(2013) , 10.1371/JOURNAL.PONE.0059711
Kirsten Falk, Olaf Rötzschke, Stefan Stevanovié, Günther Jung, Hans-Georg Rammensee, Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules. Nature. ,vol. 351, pp. 290- 296 ,(1991) , 10.1038/351290A0
Oreola A. T. Donini, Peter A. Kollman, Calculation and prediction of binding free energies for the matrix metalloproteinases. Journal of Medicinal Chemistry. ,vol. 43, pp. 4180- 4188 ,(2000) , 10.1021/JM000040D
Gang Dong, Pamela A. Wearsch, David R. Peaper, Peter Cresswell, Karin M. Reinisch, Insights into MHC class I peptide loading from the structure of the tapasin-ERp57 thiol oxidoreductase heterodimer. Immunity. ,vol. 30, pp. 21- 32 ,(2009) , 10.1016/J.IMMUNI.2008.10.018
Sebastian Springer, Klaus Döring, Jonathan C. A. Skipper, Alain R. M. Townsend, Vincenzo Cerundolo, Fast association rates suggest a conformational change in the MHC class I molecule H-2Db upon peptide binding. Biochemistry. ,vol. 37, pp. 3001- 3012 ,(1998) , 10.1021/BI9717441
L. Chen, M. Jondal, Endolysosomal Processing of Exogenous Antigen into Major Histocompatibility Complex Class I‐Binding Peptides Scandinavian Journal of Immunology. ,vol. 59, pp. 545- 552 ,(2004) , 10.1111/J.1365-3083.2004.01426.X