Maximum life span in vertebrates : relationship with liver antioxidant enzymes, glutathione system, ascorbate, urate, sensitivity to peroxidation, true malondialdehyde, in vivo H2O2, and basal and maximum aerobic capacity

摘要: In order to help clarify whether free radicals are implicated or not in the evolution of maximum life span (MLSP) animals, a comprehensive study was performed liver various vertebrate species. Strongly significant negative correlations against MLSP were found for hepatic catalase, Se-dependent and -independent glutathione peroxidases, GSH, whereas superoxide dismutase, reductase, ascorbate, uric acid, GSSG/GSH, vitro peroxidation (TBA-RS), vivo steady-state H2O2 concentration did correlate with MLSP. Superoxide peroxidase, GSH results agreement those independently reported by other authors, rest our data first time. Potential limitations arising from use animals different Classes counterbalanced possibility very MLSPs energy potentials. Furthermore, agreed previous obtained using only mammals. Since peroxidation, specially similar species widely MLSPs, it is suggested that decrease enzymatic detoxifying capacity longevous represents an evolutionary co-adaptation smaller rate radical generation. We propose longevity increased during lowering recycling tissues.