Instabilities of metabolic regulations in aging
作者： Britton Chance , William W. Bank , Cheng-dou Zhang
DOI: 10.1007/978-3-0348-7460-1_6
关键词: Biophysics 、 Oxygen 、 Internal medicine 、 Senescence 、 Menadione 、 Atp production 、 Oxygene 、 Free-radical theory of aging 、 Hyperoxia 、 Endocrinology 、 Mitochondrion 、 Chemistry
摘要: 1) That non-invasive NMR and optical methods can a) quantify the work stress on mitochondria for ATP production, b) indicate tissue O2 tension in capillary bed that is responsible rate of radical generation. 2) free damage to mitochondrial function be quantified by reciprocal plots inverse slope giving extrapolated Vm mitochondria. 3) a particular genetically deficient individual requiring high dosages menadione has survived over 9 years. 4) deficiency leads an exercise hyperoxia.
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