作者: C.D Smith , W Landrum , J.M Carney , P.W Landfield , M.J Avison
DOI: 10.1016/S0197-4580(97)00156-5
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摘要: We measured in vivo forward flux of the creatine kinase reaction rat forebrain young (Y: 6 month, n = 13), mid-aged (M: 12 7) and aged (O: 27 10) animals using 31P magnetic resonance saturation transfer. Forward was reduced rats 0.42 +/- 0.08; M: 0.41 0.10; O: 0.31 0.03 s(-1) SD; p 0.008 O vs. Y). In vitro studies a subset same showed parallel decline CK activity 2.16 0.40; 2.17 0.25; 1.56 0.06 IU S.D.; 0.002 The spectroscopic biochemical measures were significantly correlated. Reduced could account for observed decreased aging brain. Intracellular pH, phosphocreatine/inorganic phosphate ratio, phospocreatine/gamma-adenosine triphosphate ratio did not differ between groups. may represent better measure brain energy function than relative phosphocreatine or adenosine levels observable vivo.