The mitochondrial-lysosomal axis theory of aging: accumulation of damaged mitochondria as a result of imperfect autophagocytosis.
作者： Ulf T. Brunk , Alexei Terman
DOI: 10.1046/J.1432-1033.2002.02869.X
关键词: Oxidative stress 、 Myocyte 、 Enzyme 、 Nanotechnology 、 Mitochondrial Turnover 、 Cell biology 、 Reactive oxygen species 、 Mitochondrion 、 Biology 、 Organelle 、 Lipofuscin
摘要: … There is strong evidence that macromolecules become indigestible as a result of oxidative modification (associated with aggregation due to aldehyde-mediated cross-linking), and that …
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