The Importance of the Environment in Brain Aging: Be Happy, Live Longer!
作者： Mónica De la Fuente , Lorena Arranz
DOI: 10.1007/978-94-007-5237-5_6
关键词:
摘要: The prevalence of age-related neurodegenerative disorders in the elderly has dramatically increased parallel to life expectancy and social aging. This demands development effective therapeutic/preventive interventions aimed slow down negative effects aging extend health-span. Here, we overview mechanisms underlying brain context oxi-inflamm-aging theory, discuss cutting edge promising findings opening up possibility reverse physiological based on environmental enrichment. enriched environment (EE) represents an experimental approach animal models active social, mental physical life-style humans. Interaction with EE provides animals a diversion from monotonous thus stressful cage life. Most important, maintenance life-long “diversion” by means extends lifespan mice. sighting confirms great influence upon aging, suggests that “happier” are, longer might live good health.
springer.com
sci-hub.st 参考文章(104)
Vincent Roy, Catherine Belzung, Catherine Delarue, Pierre Chapillon, Environmental enrichment in BALB/c mice: effects in classical tests of anxiety and exposure to a predatory odor. Physiology & Behavior. ,vol. 74, pp. 313- 320 ,(2001) , 10.1016/S0031-9384(01)00561-3
Dustan A. Barber, Steven R. Harris, Oxygen free radicals and antioxidants: a review. American pharmacy. ,vol. 34, pp. 26- 35 ,(1994) , 10.1016/S0160-3450(15)30310-X
Jose Viña, Juan Sastre, Federico Pallardó, Consuelo Borrás, Mitochondrial Theory of Aging: Importance to Explain Why Females Live Longer Than Males Antioxidants & Redox Signaling. ,vol. 5, pp. 549- 556 ,(2003) , 10.1089/152308603770310194
Patricia Alonso-Fernández, Marta Puerto, Ianire Maté, José Manuel Ribera, Mónica De La Fuente, Neutrophils of Centenarians Show Function Levels Similar to Those of Young Adults Journal of the American Geriatrics Society. ,vol. 56, pp. 2244- 2251 ,(2008) , 10.1111/J.1532-5415.2008.02018.X
Ulf T. Brunk, Alexei Terman, The mitochondrial-lysosomal axis theory of aging: accumulation of damaged mitochondria as a result of imperfect autophagocytosis. FEBS Journal. ,vol. 269, pp. 1996- 2002 ,(2002) , 10.1046/J.1432-1033.2002.02869.X
Francisco Mora, Gregorio Segovia, Alberto del Arco, Aging, plasticity and environmental enrichment: structural changes and neurotransmitter dynamics in several areas of the brain. Brain Research Reviews. ,vol. 55, pp. 78- 88 ,(2007) , 10.1016/J.BRAINRESREV.2007.03.011
J. Miquel, A.C. Economos, J. Fleming, J.E. Johnson, Mitochondrial role in cell aging Experimental Gerontology. ,vol. 15, pp. 575- 591 ,(1980) , 10.1016/0531-5565(80)90010-8
Sebastien Couillard-Despres, Bernhard Iglseder, Ludwig Aigner, Neurogenesis, cellular plasticity and cognition: the impact of stem cells in the adult and aging brain--a mini-review. Gerontology. ,vol. 57, pp. 559- 564 ,(2011) , 10.1159/000323481
Wulf Dröge, Hyman M. Schipper, Oxidative stress and aberrant signaling in aging and cognitive decline Aging Cell. ,vol. 6, pp. 361- 370 ,(2007) , 10.1111/J.1474-9726.2007.00294.X
B.A Kinney-Forshee, N.E Kinney, R.W Steger, A Bartke, Could a deficiency in growth hormone signaling be beneficial to the aging brain Physiology & Behavior. ,vol. 80, pp. 589- 594 ,(2004) , 10.1016/J.PHYSBEH.2003.10.018