作者: Jan Škrha
DOI: 10.1016/S0065-2423(09)47008-2
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摘要: Caloric restriction is associated with a decreased level of oxidative stress. Reactive oxygen species (ROS) generated predominantly in mitochondria are attenuated by caloric intake. On the other hand, antioxidative mechanisms frequently accelerated increased gene expression or activities antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase, paraoxonase, etc.). Measurement different stress markers relationship to therefore important experimental as well clinical studies. Estimation ROS tissues and fluids typically performed measurement oxidant products (i.e., malondialdehyde, F-2-isoprostanes, nitrotyrosine) system (enzymes, glutathione, alpha-tocopherol, ascorbic acid, ubichinone, Because both components critical objectively understand state, tangible biochemical data required order comprehensively elucidate pathobiologic potential therapeutic regimes involving lifestyle changes that include moderate physical activity.