Factors Affecting Informed Decision-Making in Women with Increased Breast Cancer Risk or DCIS Pursuing Contralateral Prophylactic Mastectomy

摘要: Despite lack of survival benefit, an increasing number women diagnosed with ductal carcinoma in situ (DCIS) opt for removal the unaffected breast addition to known pathology, i.e. contralateral prophylactic mastectomy (CPM). Little is about women's decision-making processes that contribute this rising trend, particularly DCIS. Further obscuring decision highly variable terminology used discuss cancer pathologies and treatments. The purpose study was investigate factors impacting risk comprehension related increased or We conducted a retrospective prospective pilot evaluate perceived risk, health literacy, numeracy, terms genetics cancer. Clinical data such as MRI, genetic testing, family history, derived from predictive models were also collected. Women DCIS those high-risk development invasive eligible, 68 patients participated. Of cohort, 33 (48.5%) considered pursuing CPM 11 (16.2%) underwent CPM. Anxiety recurrence top reason considering Undergoing significantly associated plastic surgery consultation, 10-year counseling, testing. consideration higher incomes. Numeracy, scores not significant predictors Lastly, 83.8% respondents stated qualified cancer, but only 39.7% correctly defined When asked interpret phrase “indolent lesion epithelial origin” (new advocated replace “DCIS”), 27.9% believed it referred 47.1% did not, 23.5% unsure. Patients commonly thought “lesion” meant “skin wound” “sore”. Decision-making remains complex. Although has shown advantage can have complications, rates continue rise. Recognizing patients' knowledge communication vital support shared informed surgical decisions. The following are 20 highest scoring abstracts submitted presentation at 39th Annual ASPO meeting held March 15–17, 2015, Birmingham, AL.