The effects of the genotype and social stress on cAMP- and substrate-dependent mechanism regulating the hormone-producing function of mouse testes

摘要: Several steps of cAMP- and substrate-dependent testosterone production in the testes were studied with laboratory mouse micropopulations six inbred strains (A/He, CBA/Lac, C57Bl/6J, DD, YT, PP). The differed basal gonads its response to activation adenylate cyclase signal transduction pathway at various by human chorionic gonadotropin (hCG), cholera toxin, forskolin, dibutyryl-cAMP presence pregnenolone, an early precursor testosterone. Establishment dominant–subordinate relationships populations substantially affected all activators testicular steroidogenesis. secretory activity decreased establishment social hierarchy experimental micropopulations, then returned initial level, again case hCG, dibutyryl-cAMP, pregnenolone. With steroidogenesis, activated changed same direction during maintenance hierarchy, suggesting coordinated changes examined biosynthesis testes. among-strain differences steroidogenesis remained much stages hierarchy. parameters averaged over individual proved associated. Their genotypic correlations positive and, many cases, significant. Subsequent component analysis showed that one principal accounted for more than 80% total variation, a genetic control endocrine function