Quantitative Comparison of Endocytosis and Intracellular Trafficking of DNA/Polymer Complexes in the Absence/Presence of Free Polycationic Chains
作者： Yue Yanan
DOI: 10.1007/978-3-319-00336-8_4
关键词: DNA 、 Transfection 、 Intracellular 、 Biochemistry 、 Nucleic acid 、 Polymer 、 Polyethylenimine 、 Cationic polymerization 、 Endocytosis 、 Biophysics 、 Chemistry
摘要: The development of smart and multi-functional non-viral polymeric devices (NVPD) for nucleic acid delivery has captured tremendous attention over the past few decades [1–3]. Particularly, cationic polymers are perceived as promising candidates due to their safety profiles relative ease incorporate desired functional moieties[4, 5]. Currently, polyethylenimine (PEI) is among most intensively studied vehicles hitherto mediates nearly highest in vitro transfection efficiency absence any exogenous endosomolytic agent [6–8].
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