Cellular uptake of cationic polymer-DNA complexes via caveolae plays a pivotal role in gene transfection in COS-7 cells.
作者： M. A. E. M. van der Aa , U. S. Huth , S. Y. Häfele , R. Schubert , R. S. Oosting
DOI: 10.1007/S11095-007-9287-3
关键词: Genetic transfer 、 Endocytosis 、 COS cells 、 Beta-Cyclodextrins 、 Biochemistry 、 Cell biology 、 Gene delivery 、 Caveolae 、 Intracellular 、 Biology 、 Transfection
摘要: Purpose Knowledge about the uptake mechanism and subsequent intracellular routing of non-viral gene delivery systems is important for development more efficient carriers. In this study we compared two established cationic polymers pDMAEMA PEI with regard to their transfection efficiency cellular uptake.
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