Induced Pluripotency for the Study of Disease Mechanisms and Cell Therapy

摘要: Pluripotent cells including induced pluripotent stem (iPS) are regarded as a powerful source for cell therapy, because these function both by direct replacement and also paracrine effects. Advantage of iPS is their unlimited availability. In this chapter we characterize the state starting from embryonic (ES) comparing them with cells. We describe different ways using cells: damaged in combination gene therapy. summarize recent achievements areas conclude that although developments highly promising, there still potential risks adverse effects, which need more fundamental research before therapy will become routine clinical practice. One promising area technology derivation patients genetic or other disorders use “human model human disease” to understand mechanisms disease possibly find new chemicals correct defective pathways. This approach has already led discoveries routes medical treatments potentially form efficient basis personalized patients.