DOI: 10.1016/S0190-9622(82)70072-6
关键词: Melanoma 、 Retinoic acid 、 Secondary prevention 、 Bacille Calmette Guerin 、 Vitamin a acid 、 Adjuvant 、 Dysplasia 、 Medicine 、 Cancer research 、 Cancer 、 Immunology 、 Dermatology
摘要: Investigation of retinoids for anticancer activity in humans, either the chemopreventive or treatment mode, has been little studied. We summarize here our ongoing investigations four different areas: (1) secondary prevention cervical dysplasia with topical application all- trans -retinoic acid; (2) adjuvant resected high-risk stage I and II malignant melanoma bacille Calmette Guerin (BCG) plus minus oral vitamin A; (3) A acid therapy cutaneous metastatic melanoma; (4) isotretinoin as an agent.