Topical Tretinoin (Retinoic Acid) Treatment for Liver Spots Associated with Photodamage

摘要: Abstract Background. The hyperpigmented lesions commonly called liver spots distress patients, in part because such are associated with aging. We investigated their treatment topical 0.1 percent tretinoin (retinoic acid). Methods. Fifty-eight patients completed a 10-month randomized, double-blind study which they applied either (n = 28) or vehicle 30) cream daily to the face, upper extremities, both. Fifteen who responded well were then randomly assigned continue therapy use alone for six more months. Patients evaluated by physical examination every month and analysis of biopsy specimens obtained at base line end trial. Results. After one treated had significant lightening as compared received (P<0.002). 10 months, 20 (83 percent) 24 facial we...