Prevalence and risk factors of extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae in an Israeli long-term care facility.

摘要: The purpose of this study was to ascertain the prevalence extended-spectrum beta-lactamases (ESBLs) among Escherichia coli and Klebsiella pneumoniae strains obtained from urine samples residents a long-term care facility determine risk factors for acquisition ESBL-producing strains. All collected January 2003 October that were positive E. or K. tested presence ESBL. Records patients with ESBL-positive (ESBL-P) analyzed clinical demographic data. records matched control group whose but ESBL-negative (ESBL-N) also analyzed. overall rate ESBLs 25.6%. Of 350 grew coli, 77 (22%) ESBL; 34 84 (40.5%) ESBL-P. Male sex, treatment in subacute unit, recent antimicrobial treatment, pressure sores, (percutaneous endoscopic gastrostomy) PEG tube, anemia, hypoalbuminemia, permanent urinary catheter, any invasive procedure all associated ESBL-P bacteria univariate analysis. multivariate analysis revealed three independent an strain: previous antibiotic use. Fluoroquinolones most strongly development bacteria. investigated unexpectedly high corroborates notion facilities could be important reservoirs resistant Identification is first step formulating effective strategy curtail spread ESBL resistance facilities.