Effects of paediatric HIV infection on electrical conduction of the heart

摘要: Objective To investigate the effects of HIV infection in children on heart electrical conduction, particularly to delineate from treatment. Methods On a 12-lead ECG, available for 37 antiretroviral therapy (ART) naive, 42 ART-exposed vertically-acquired HIV-infected and 50 healthy Jakarta, Indonesia, we measured cardiac conduction parameters: PR, QRS, QTc (corrected using Bazett9s formula) intervals. The associations between infection/treatment status ECG intervals were evaluated general linear modelling with further adjustment potential confounders or intermediary variables. Findings are presented as (adjusted) mean differences each two groups children. Results Although not exceeding clinical threshold long QT (QTc >460 ms girls >440 boys) compared children, longer ART-naive (difference 18.2 ms, 95% CI 7.0 29.3) and, greater extent, 28.9 ms, 19.3 38.5). Following RR interval, age height, prolongation PR interval was seen only 12.9 ms, 2.4 23.3). Cardiac mass/function, high-sensitive C reactive protein, cholesterol glycated haemoglobin levels, systolic diastolic blood pressures, postnatal parental smoking exposure did affect these associations. No difference QRS observed groups. Conclusions Prolongation occurs whereas appears be among