PRAD1, a candidate BCL1 oncogene: mapping and expression in centrocytic lymphoma.

摘要: Abstract Rearrangement of the BCL1 (B-cell lymphoma 1) region on chromosome 11q13 appears to be highly characteristic centrocytic and also is found infrequently in other B-cell neoplasms. Rearrangement thought deregulate a nearby protooncogene, but transcribed sequences immediate vicinity breakpoints had not been identified. PRAD1, previously designated D11S287E, was identified as chromosomal breakpoint rearranged with parathyroid hormone gene subset adenomas; this conserved putative oncogene, which encodes novel cyclin, has linked implicated subsets breast squamous cell neoplasms amplification. We report pulsed-field gel electrophoresis data showing PRAD1 no more than 130 kilobases apart. mRNA abundantly expressed seven lymphomas (Kiel classification), contrast 13 closely related noncentrocytic lymphomas. Three detectable DNA rearrangement. Also, two unusual cases CLL rearrangement overexpressed five controls. Thus, an excellent candidate "BCL1 oncogene." Its overexpression may key consequence unifying pathogenetic feature lymphoma.