Effect of simvastatin therapy on blood and tissue ATP levels and erythrocyte membrane lipid composition.
作者： S Calişkan , M Calişkan , F Kuralay , B Onvural , None
DOI:
关键词: Cholesterol 、 Triglyceride 、 Membrane 、 Biochemistry 、 Electron transport chain 、 Red blood cell 、 Chemistry 、 Internal medicine 、 Coenzyme A 、 Reductase 、 Endocrinology 、 Simvastatin
摘要: 3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors decrease mevalonate and subsequently cholesterol synthesis competitively. Mevalonate is also the precursor of ubiquinone. Ubiquinone an important component electron transport chain. We therefore investigated effect simvastatin on rat blood tissue ATP concentrations lipid composition red cell membranes after 4 weeks therapy. Significant reductions in plasma cholesterol, triglyceride, were detected. Tissue levels not affected. Membrane phospholipids increased, while to phospholipid ratio decreased (P < 0.05). positive correlation between concentration was noted 0.05, r = 0.851). Our results show that HMG-CoA change probably functions membrane lipids concentration.
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