Effects of Lowering Average or Below-Average Cholesterol Levels on the Progression of Carotid Atherosclerosis Results of the LIPID Atherosclerosis Substudy
作者： Stephen MacMahon , Norman Sharpe , Greg Gamble , Hamish Hart , John Scott
DOI: 10.1161/01.CIR.97.18.1784
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摘要: Background—Cholesterol lowering in patients with above-average cholesterol levels has been shown to reduce the progression of atherosclerosis and lower risk coronary heart disease events. However, there uncertainty about effects average or below-average levels. Methods Results—In this study, 522 a history myocardial infarction unstable angina baseline total between 4 7 mmol/L (mean, 5.7 mmol/L) were randomized treatment low fat diet plus pravastatin (40 mg daily) placebo. Treatment reduced by 19%, LDL 27%, apolipoprotein B triglycerides 13% (all 2P<.0001) increased A1 HDL 4% (both 2P<.0005), comparison Carotid was assessed from B-mode ultrasound measurements common carotid artery...
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