Type 2 Diabetes Medication Review.

作者: James J. Sterrett , Scott Bragg , Charles Wayne Weart

DOI: 10.1016/J.AMJMS.2016.01.019

关键词: Alternative medicineTolerabilityPatient centeredPharmacotherapyPharmacologyRisks and benefitsMedicineType 2 diabetesDrug Utilization ReviewMedication reviewIntensive care medicine

摘要: Abstract Background Patients with type 2 diabetes and their healthcare providers have a variety of medication options available for treating elevated blood glucose values. These choices expanded drastically over the last 10 years large number lowering medications gaining FDA approval. Methods Here, we included an extensive search literature focusing on articles which impact patient-oriented evidence that maters (POEMs). Results Choosing best agent(s) can be challenging requires weighing risks benefits each particular medication. Tailoring to individual patients should prioritized based trials cardiovascular outcome data, potential hemoglobin A1c reduction/goal, serious precautions side-effects, co-morbid medical conditions, cost. Conclusions This paper will provide reader overview pros cons antiglycemic class specific drugs where appropriate. Data relevant most patient centered encounters provided, including safety, tolerability, efficacy, cost, simplicity use.

参考文章(61)
Benjamin M Scirica, Deepak L Bhatt, Eugene Braunwald, P Gabriel Steg, Jaime Davidson, Boaz Hirshberg, Peter Ohman, Robert Frederich, Stephen D Wiviott, Elaine B Hoffman, Matthew A Cavender, Jacob A Udell, Nihar R Desai, Ofri Mosenzon, Darren K McGuire, Kausik K Ray, Lawrence A Leiter, Itamar Raz, Saxagliptin and Cardiovascular Outcomes in Patients with Type 2 Diabetes Mellitus The New England Journal of Medicine. ,vol. 369, pp. 1317- 1326 ,(2013) , 10.1056/NEJMOA1307684
Helena W Rodbard, Virginia E Visco, Henning Andersen, Line C Hiort, David HW Shu, Treatment intensification with stepwise addition of prandial insulin aspart boluses compared with full basal-bolus therapy (FullSTEP Study): a randomised, treat-to-target clinical trial The Lancet Diabetes & Endocrinology. ,vol. 2, pp. 30- 37 ,(2014) , 10.1016/S2213-8587(13)70090-1
JA Hirst, AJ Farmer, A Dyar, TWC Lung, RJ Stevens, None, Estimating the effect of sulfonylurea on HbA1c in diabetes: a systematic review and meta-analysis Diabetologia. ,vol. 56, pp. 973- 984 ,(2013) , 10.1007/S00125-013-2856-6
Yasuo Ohkubo, Hideki Kishikawa, Eiichi Araki, Takao Miyata, Satoshi Isami, Sadatoshi Motoyoshi, Yujiro Kojima, Naohiko Furuyoshi, Motoaki Shichiri, Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study. Diabetes Research and Clinical Practice. ,vol. 28, pp. 103- 117 ,(1995) , 10.1016/0168-8227(95)01064-K
E. Erdmann, E. Song, R. Spanheimer, A.-R. van Troostenburg de Bruyn, A. Perez, Observational follow‐up of the PROactive study: a 6‐year update Diabetes, Obesity and Metabolism. ,vol. 16, pp. 63- 74 ,(2014) , 10.1111/DOM.12180
Donald S. Fong, Richard Contreras, Glitazone use associated with diabetic macular edema. American Journal of Ophthalmology. ,vol. 147, pp. 583- 586 ,(2009) , 10.1016/J.AJO.2008.10.016
Kenneth W Mahaffey, Gail Hafley, Sheila Dickerson, Shana Burns, Sandra Tourt-Uhlig, Jennifer White, L Kristin Newby, Michel Komajda, John McMurray, Robert Bigelow, Philip D Home, Renato D Lopes, None, Results of a reevaluation of cardiovascular outcomes in the RECORD trial American Heart Journal. ,vol. 166, pp. 240- 249.e1 ,(2013) , 10.1016/J.AHJ.2013.05.004
Alan J. Garber, Martin J. Abrahamson, Joshua I. Barzilay, Lawrence Blonde, Zachary T. Bloomgarden, Michael A. Bush, Samuel Dagogo-Jack, Michael B. Davidson, Daniel Einhorn, Jeffrey R. Garber, W. Timothy Garvey, George Grunberger, Yehuda Handelsman, Irl B. Hirsch, Paul S. Jellinger, Janet B. McGill, Jeffrey I. Mechanick, Paul D. Rosenblit, Guillermo Umpierrez, Michael H. Davidson, AACE/ACE COMPREHENSIVE DIABETES MANAGEMENT ALGORITHM 2015 Endocrine Practice. ,vol. 21, pp. 438- 447 ,(2015) , 10.4158/EP15693.CS