Variability of HIV infections

摘要: Genetic variation is the hallmark of infections with lentiviruses in general and human immunodeficiency viruses (HIV-1, HIV-2) particular. This article reviews both experimental evidence for variability HIV genome during course an individual infection mathematical models that outline potential importance antigenic as a major factor to drive disease progression. The essential idea virus evades immune pressure by continuous production new mutants resistant current immunological attack. results accumulation diversity asymptomatic period. existence threshold derived from asymmetric interaction between quasispecies CD4 cell population: cells mount responses some which are directed against specific variants, but each strain can induce depletion all therefore impair regardless their specificity. Therefore, increasing enables population escape control system. In this context observed genetic responsible fact establishes persistant without being cleared response induces after long variable incubation Mathematical biology has revealed novel mechanism viral pathogenesis.