Aberrant immunophenotypes of mantle cell lymphomas.
作者： Ch. Wohlschlaeger , K. Lange , H. Merz , A.C. Feller
DOI: 10.1080/1042819021000035653
关键词: CD23 、 CD5 、 Cell 、 Immunohistochemistry 、 Immunophenotyping 、 Mantle cell lymphoma 、 Biology 、 Pathology 、 Differential diagnosis 、 Cyclin D1
摘要: Mantle cell lymphomas (MCL) are characterized by cytomorphological criteria, a distinct immunophenotype and characteristic chromosomal aberration (t(11;14)). In morphological variants of MCL the immunohistochemical constellation with CD5-positivity CD23-negativity is helpful decisive diagnostic aid to differentiate from other B-cell-lymphomas, e.g. lymphocytic (B-CLL). this study morphological, immunophenotypical, genetical features 50 were analysed. Five cases revealed an aberrant lacking expression CD5 (n =3) positive reactivity CD23 =2) while cyclin D1 could be demonstrated in all 5 cases. These constellations show that there is, besides subgroups, small group immunophenotypes, which has taken into account differential diagnosis lymphoma lymphomas.
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