Effects of Thalidomide on Parameters Involved in Angiogenesis: An in vitro Study
作者： M. Gelati , E. Corsini , S. Frigerio , B. Pollo , G. Broggi
关键词: Thalidomide 、 Endothelial stem cell 、 Antibacterial agent 、 Medicine 、 Angiogenesis 、 Cancer research 、 Cell growth 、 Cytokine 、 Interleukin 8 、 Internal medicine 、 Vitronectin 、 Endocrinology
摘要: In an attempt to elucidate the mechanism(s) of action thalidomide, a reportedly antiangiogenic molecule recently tested in treatment relapsing malignant gliomas, we performed vitro study on following parameters: (a) effect thalidomide proliferation endothelial cells; (b) expression αvβ3 integrin surface (c) release by cells MMP-2, IL-8 and TNF-α. The results show that inhibits endotelial cell induced bFGF VEGF, more so if are grown vitronectin; moreover, with reduces MMP-2 cells, suggesting further pathway for activity drug. On other hand, does not modify cells.
springer.com
elsevier.com
sci-hub.se 参考文章(23)
André Luís Moreira, David Raul Friedlander, Bronya Shif, Gilla Kaplan, David Zagzag, Thalidomide and a thalidomide analogue inhibit endothelial cell proliferation in vitro. Journal of Neuro-oncology. ,vol. 43, pp. 109- 114 ,(1999) , 10.1023/A:1006202700039
Gavin M. Marx, Nicholas Pavlakis, Sally McCowatt, Frances M. Boyle, John A. Levi, David R. Bell, Raymond Cook, Michael Biggs, Nicholas Little, Helen R. Wheeler, Phase II study of thalidomide in the treatment of recurrent glioblastoma multiforme. Journal of Neuro-oncology. ,vol. 54, pp. 31- 38 ,(2001) , 10.1023/A:1012554328801
M.L. Douglas, J.L. Reid, S.I. Hii, J.R. Jonsson, D.L. Nicol, Renal cell carcinoma may adapt to and overcome anti-angiogenic intervention with thalidomide BJU International. ,vol. 89, pp. 591- 595 ,(2002) , 10.1046/J.1464-410X.2002.02666.X
Regina Fillbrandt, Katrin Lamszus, Ulrike Ulbricht, Philip Kunkel, Manfred Westphal, Dimitrios Stavrou, Marc A. Brockmann, Peter Bohlen, Inhibition of glioma angiogenesis and growth in vivo by systemic treatment with a monoclonal antibody against vascular endothelial growth factor receptor-2. Cancer Research. ,vol. 61, pp. 6624- 6628 ,(2001)
Valeria Lucini, Mauro Pluderi, Giorgio Carrabba, Roberto M. Villani, Demetrios Nikas, Jianping Zhang, Peter M. Black, Giustino Tomei, Marcelle Machluf, Rona S. Carroll, Andreas Bikfalvi, Lorenzo Bello, Carlo Giussani, Simultaneous inhibition of glioma angiogenesis, cell proliferation, and invasion by a naturally occurring fragment of human metalloproteinase-2. Cancer Research. ,vol. 61, pp. 8730- 8736 ,(2001)
Giulio Alessandri, Renato G.S. Chirivi, Simona Fiorentini, Romina Dossi, Stefano Bonardelli, Stefano Maria Giulini, Gerardo Zanetta, Fabio Landoni, Pier Paolo Graziotti, Adolfo Turano, Arnoldo Caruso, Luciano Zardi, Raffaella Giavazzi, Maria Rosa Bani, Phenotypic and functional characteristics of tumour-derived microvascular endothelial cells Clinical & Experimental Metastasis. ,vol. 17, pp. 655- 662 ,(1999) , 10.1023/A:1006738901839
Oscar Arrieta, Patricia Guevara, Joaquin Tamariz, Daniel Rembao, Erika Rivera, Julio Sotelo, None, Antiproliferative effect of thalidomide alone and combined with carmustine against C6 rat glioma. International Journal of Experimental Pathology. ,vol. 83, pp. 99- 104 ,(2002) , 10.1046/J.1365-2613.2002.00219.X
Edmond A. Knopp, David Zagzag, Glyn Johnson, Michael L. Gruber, Stanley Lu, Andrew Litt, Soonmee Cha, Jon Glass, Dynamic Contrast-enhanced T2*-weighted MR Imaging of Recurrent Malignant Gliomas Treated with Thalidomide and Carboplatin American Journal of Neuroradiology. ,vol. 21, pp. 881- 890 ,(2000)
Warren L. Garner, Michael Hughes, Tai Lan Tuan, Huayang Wu, Yuan Ping Han, TNF-alpha stimulates activation of pro-MMP2 in human skin through NF-(kappa)B mediated induction of MT1-MMP. Journal of Cell Science. ,vol. 114, pp. 131- 139 ,(2001) , 10.1242/JCS.114.1.131
Howard A. Fine, William D. Figg, Kurt Jaeckle, Patrick Y. Wen, Athanassios P. Kyritsis, Jay S. Loeffler, Victor A. Levin, Peter M. Black, Richard Kaplan, James M. Pluda, W.K. Alfred Yung, Phase II Trial of the Antiangiogenic Agent Thalidomide in Patients With Recurrent High-Grade Gliomas Journal of Clinical Oncology. ,vol. 18, pp. 708- 715 ,(2000) , 10.1200/JCO.2000.18.4.708