A new peptide ligand for colon cancer targeted delivery of micelles

作者: Yachao Ren , Yu Mu , Yanping Song , Jinxin Xie , Hui Yu

DOI: 10.3109/10717544.2015.1077293

关键词: MicelleTargeted drug deliveryLigand (biochemistry)ChemistryFlow cytometryTargeted therapyPeptideBioinformaticsBiophysicsIntegrinCytotoxicity

摘要: Ligands are an imperative part of targeted drug delivery systems, and choosing a ligand with high affinity is a subject of considerable interest. In this study, we first synthesized a 12-…

参考文章(51)
Leo E. Gerweck, Kala Seetharaman, Cellular pH gradient in tumor versus normal tissue : Potential exploitation for the treatment of cancer Cancer Research. ,vol. 56, pp. 1194- 1198 ,(1996)
Richard O. Hynes, Integrins: Bidirectional, Allosteric Signaling Machines Cell. ,vol. 110, pp. 673- 687 ,(2002) , 10.1016/S0092-8674(02)00971-6
Dermot Cox, Marian Brennan, Niamh Moran, Integrins as therapeutic targets: lessons and opportunities Nature Reviews Drug Discovery. ,vol. 9, pp. 804- 820 ,(2010) , 10.1038/NRD3266
Charles R Martin, Nanomedicine: a great first year and, with your help, a bright future ahead Nanomedicine: Nanotechnology, Biology and Medicine. ,vol. 2, pp. 265- 266 ,(2007) , 10.2217/17435889.2.3.265
Hehong Ni, David Gagne, Nuria Basora, Jean-Francois Beaulieu, Up-regulation of the α6β4 integrin in human colon cancer cells Gastroenterology. ,vol. 120, pp. A61- ,(2001) , 10.1016/S0016-5085(08)80301-0
J. L. Arias, Drug targeting strategies in cancer treatment: an overview. Mini-reviews in Medicinal Chemistry. ,vol. 11, pp. 1- 17 ,(2011) , 10.2174/138955711793564024
Jianli Zhang, Jun Gao, Xiaojie Tan, Min Wang, Renyi Qin, Effects of down-regulation of integrin-β1 expression on migration and hepatic metastasis of human colon carcinoma Journal of Huazhong University of Science and Technology [Medical Sciences]. ,vol. 30, pp. 464- 469 ,(2010) , 10.1007/S11596-010-0450-4
Robert Karlsson, Anders Fält, Experimental design for kinetic analysis of protein-protein interactions with surface plasmon resonance biosensors Journal of Immunological Methods. ,vol. 200, pp. 121- 133 ,(1997) , 10.1016/S0022-1759(96)00195-0
Masamichi Nagae, Suyong Re, Emiko Mihara, Terukazu Nogi, Yuji Sugita, Junichi Takagi, Crystal structure of α5β1 integrin ectodomain: Atomic details of the fibronectin receptor Journal of Cell Biology. ,vol. 197, pp. 131- 140 ,(2012) , 10.1083/JCB.201111077
Ruei-Zhen Lin, Hwan-You Chang, Recent advances in three-dimensional multicellular spheroid culture for biomedical research Biotechnology Journal. ,vol. 3, pp. 1172- 1184 ,(2008) , 10.1002/BIOT.200700228