Prolonged circulation and increased tumor accumulation of liposomal vincristine in a mouse model of rhabdomyosarcoma
作者： Maurizio Roveri , Alice Pfohl , Patricia Jaaks , Nagjie Alijaj , Jean-Christophe Leroux
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摘要: Aim: Our goal was to improve vincristine (VCR) based rhabdomyosarcoma (RMS) therapy by encapsulating the drug into liposomes. A targeting strategy attempted enhance tumor accumulation. Materials & methods: VCR loaded in control and peptide-decorated liposomes via an active method. The interaction of RMS-specific peptide with presumed target furin cellular uptake both liposomal groups were studied vitro. Pharmacokinetics biodistribution VCR-containing assessed RMS xenograft mouse model. Results: Liposomes ensured high concentration plasma tumor. Peptide-decorated showed modest cells. Conclusion: investigated peptide-modified formulation may not be optimal for furin-mediated targeting. Nevertheless, VCR-loaded could serve as a delivery platform experimental RMS.
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