Metabolic and Neurophysiologic Sequelae of Brain Injury: A Cholinergic Hypothesis
作者： RONALD L. HAYES , HENRY H. STONNINGTON , BRUCE G. LYETH , CLIFTON E. DIXON , TAKAMITSU YAMAMOTO
关键词: Reticular activating system 、 Anesthesia 、 Cholinergic 、 Microinjection 、 Carbachol 、 Electroencephalography 、 Acetylcholine 、 Neuroscience 、 Coma 、 Concussion 、 Psychology
摘要: ABSTRACT This paper reviews a number of lines evidence developed in our laboratories indicating that at least some components neurologic disturbances following concussion may be attributable to increased functional activity cholinergic systems located within specific brain regions. These include (1) EEG studies disruption the reticular activating system is not necessary for production reversible, flaccid, comatose state low levels concussion, (2) systematic transection regions bounded by collicular and midpontine transections contribute motor behavioral suppression associated with (3) local rates glucose utilization fluid percussion injury increase restricted areas transections; microinjection carbachol (but tetracaine) into these hypermetabolic produced electroencephalographic ch...
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