Treatment of immunoglobulin G4-related sialadenitis: outcomes of glucocorticoid therapy combined with steroid-sparing agents

摘要: Immunoglobulin G4-related sialadenitis (IgG4-RS) is a newly recognized immune-mediated systemic disease. Despite its good response to steroid therapy, treatment protocol not standardized and the long-term outcome controversial. The study was conducted determine short-term outcomes of IgG4-RS patients treated with glucocorticoids steroid-sparing immunosuppressive agents, analyze secretory function, serological radiological changes in salivary glands assess usefulness serum IgG4 level as an indicator disease activity. who were for more than 3 months enrolled. Serological tests, gland function assessment computed tomography (CT) performed before during follow up. short long term evaluated, relationship between volume analyzed. Glucocorticoids used all 43 agents 38 (88.4%). follow-up period 24.6 ± 14.9 months. Clinical remission achieved after induction therapy. During observation, secretion significantly increased, levels, volumes CT values submandibular parotid decreased (P < 0.001). For term, relapse occurred 32.5% within 55 months regularly group, while seven irregularly relapsed. However, relapse-free survival curves different monotherapy combination therapy groups (P = 0.566). Submandibular glands, lacrimal sublingual nasal paranasal cavity commonly relapsing organs. In clinically stable patients, serologically unstable condition 54.9% medication adjustment accordingly. Volume associated levels time up (R2adjusted = 0.905, P < 0.0001 R2adjusted = 0.9334, P < 0.0001, respectively). glucocorticoid could be effective treating IgG4-RS, restoring function. Serum predict