Comorbid diseases of IgG4‐related sialadenitis in the head and neck region

摘要: Objectives/Hypothesis To further recognize the comorbid diseases of immunoglobulin G4-related sialadenitis (IgG4-RS) in head and neck region to observe response these conditions immunomodulatory therapy. Study Design Retrospective review. Methods The symptoms medical histories 51 patients (24 men, 27 women; median age, 55 years) diagnosed with IgG4-RS were analyzed. Thirty-six received therapy followed up for 10.4 ± 5.9 months. Computed tomography (CT) examination was performed before after therapy. Results Rhinosinusitis occurred 58.8% patients, manifested nasal obstruction, xerosis, hyposmia. In addition, 43.1% had allergic rhinitis. Lymphadenopathy identified 74.5% patients. Lacrimal gland swelling 78.4% Extraocular muscles, otologic organs, skin superficial soft tissue, cranial nerves also involved. All lesions relieved therapy. The Lund-Mackay scores decreased (9.6 ± 5.6 1.0 ± 2.2) according CT analyses (P < .05). Mean volumes swollen lymph nodes lacrimal glands from 1.21 ± 0.61 cm3 0.59 ± 0.35 2.25 ± 1.35 0.70 ± 0.32 cm3, respectively (P < .05) treatment. Conclusions IgG4-RS could potentially develop involvement ocular adnexa, sinonasal cavities, ears, nodes, region. Immunomodulatory be effective controlling both major salivary glands. Level Evidence 4 Laryngoscope, 125:2113–2118, 2015