Three-dimensional macro-scale assessment of regional and temporal wall shear stress characteristics on aortic valve leaflets

摘要: The aortic valve (AV) achieves unidirectional blood flow between the left ventricle and aorta. Although hemodynamic stresses have been shown to regulate valvular biology, native wall shear stress (WSS) experienced by AV leaflets remains largely unknown. objective of this study was quantify computationally macro-scale leaflet WSS environment using fluid–structure interaction modeling. An arbitrary Lagrangian–Eulerian approach implemented predict dynamics in a three-dimensional geometry subjected physiologic transvalvular pressure. Local characteristics were quantified terms temporal magnitude (TSM), oscillatory index (OSI) gradient (TSG). dominant radial predicted on exhibited high amplitude unidirectionality ventricularis (TSM>7.50 dyn/cm2, OSI  325.54 dyn/cm2 s) but low bidirectionality fibrosa (TSM  0.38, TSG < 191.17 dyn/cm...