Expedient Pathway into Optically Active 2-Oxopiperidines
作者： Sebastiaan Bas A. M. W. van den Broek , Peter G. W. Rensen , Floris L. van Delft , Floris P. J. T. Rutjes
关键词: Chemistry 、 Piperidine 、 Ring (chemistry) 、 Ring-closing metathesis 、 Organic chemistry 、 General interest 、 Metathesis 、 Chemical synthesis 、 Optically active 、 Cyclic compound 、 Physical and Theoretical Chemistry
摘要: The piperidine ring system is one of the most common structural subunits and found in many natural products. Moreover, alkaloids derivatives thereof are great interest for pharmaceutical industry since they exhibit a wide range biological activities. Consequently, short valuable routes to highly functionalized building blocks this important general interest. A ring-closing metathesis (RCM)-mediated approach based on linear (substituted) dehydroamino esters was developed provide cyclic esters. These structures represent intermediates en route substituted pipecolic acids as well more elaborate heterocycles.
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