"Customizable" units in Di- and tripeptides: Selective conversion into substituted dehydroamino acids
作者： Carlos J. Saavedra , Alicia Boto , Rosendo Hernández
DOI: 10.1021/OL301676Z
关键词:
摘要: The selective conversion of serine or threonine units di- and tripeptides into substituted dehydroamino acids is reported. Thus, these common α-amino undergo a scission–phosphorylation process to give phosphonate residues. A Horner–Wadsworth–Emmons reaction with aldehydes ketones follows afford the final products excellent Z-stereoselectivity (Z:E > 98:2). In this way, single peptide precursor can selectively be transformed variety derivatives.
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