Candidate cell substrates, vaccine production, and transmissible spongiform encephalopathies.
作者： Pedro Piccardo , Larisa Cervenakova , Irina Vasilyeva , Oksana Yakovleva , Igor Bacik
关键词: Creutzfeldt-Jakob Syndrome 、 Infectivity 、 Bovine spongiform encephalopathy 、 Scrapie 、 Cell 、 Vero cell 、 Virology 、 Cell culture 、 Transmissible spongiform encephalopathy 、 Biology
摘要: Transmissible spongiform encephalopathy (TSE) agents have contaminated human tissue-derived medical products, blood components, and animal vaccines. The objective of this study was to determine the potential susceptibility infection 5 cell lines used or proposed for manufacture biological as well other lines. Cell were exposed infectious sporadic variant Creutzfeldt-Jakob disease bovine (BSE). Exposed cultures tested TSE-associated prion protein (PrP(TSE)) TSE infectivity by assay in rodents nonhuman primates. No PrP(TSE) has been detected any line under so far. Animals inoculated with BSE brain homogenate developed typical encephalopathy. In contrast, animals cells agent remained asymptomatic. All we studied resisted 3 agents, including agent.
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