Control of cytoplasmic dynein force production and processivity by its C-terminal domain
作者： Matthew P. Nicholas , Peter Höök , Sibylle Brenner , Caitlin L. Wynne , Richard B. Vallee
DOI: 10.1038/NCOMMS7206
关键词: Genetics 、 Cell biology 、 Processivity 、 Protein structure 、 Peptide sequence 、 Dynein 、 Cytoplasmic dynein 、 Yeast 、 C-terminus 、 Biology 、 Cytoplasm
摘要: Cytoplasmic dynein from the yeast S. cerevisiae behaves distinctly mammalian dyneins, despite structural conservation. Here, Nicholas et al. identify a C-terminal domain in that restricts force generation and travel distance, which, when removed, allows to behave like its counterpart.
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