Application of hiPSCs in tooth regeneration via cellular modulation.

摘要: BACKGROUND Induced pluripotent stem cell (iPSC)-based technology provides limitless resources for customized development of organs without any ethical concerns. In theory, iPSCs generated from terminally differentiated cells can be induced to further differentiate into all types that are derived the embryonic germ layers. Since iPSC reprogramming is relatively new, extensive efforts by researchers have been put together optimize protocols establish in vitro differentiation human (hiPSCs) various desirable types/organs. HIGHLIGHTS present study, we review potential application as an efficient alternative primary modulating signal molecules. Furthermore, culture system promotes lineages and tissue formation has reviewed. We also summarize recent studies wherein engineering three layers explored. Particularly, focus on current research strategies iPSC-based tooth regeneration via molecular modulation. CONCLUSION decades, robust knowledge regarding hiPSC-based regenerative therapy accumulated, especially focusing cellular This optimization procedures designed regenerate specific organs.