Metabolomic Signatures of Inbreeding at Benign and Stressful Temperatures in Drosophila melanogaster

摘要: While the population genetics of inbreeding is fairly well understood, effects on physiological and biochemical levels are not. Here we have investigated Drosophila melanogaster metabolome. Metabolite fingerprints in males from five outbred inbred lines were studied by nuclear magnetic resonance spectroscopy after exposure to benign temperature, heat stress, or cold stress. In both absence presence temperature metabolite significantly different among lines. The major effect was increased maltose decreased 3-hydroxykynurenine a galactoside [1-O-(4-O-(2-aminoethyl phosphate)-β-d-galactopyranosyl)-x-glycerol] synthesized exclusively paragonial glands species, including D. melanogaster. metabolomic at related gene expression data same Both indicate that fundamental metabolic processes changed modified inbreeding. Apart affecting mean levels, led an between-line variation profiles compared contrast previous observations revealing interactions between environmental stress patterns life-history traits, profile similar across treatments.