Tissues Specific Action of Thyroid Hormones: Insights from Knock out Animal Models
作者： Michelina Plateroti , Cristina Angelin-Duclos , Frederic Flamant , Jacques Samarut
DOI: 10.1007/978-1-4020-7852-1_2
关键词: Biology 、 Function (biology) 、 Thyroid hormone receptor 、 Thyroid 、 Gene 、 Congenital hypothyroidism 、 Hormone 、 Cell biology 、 In vivo 、 Metamorphosis
摘要: Thyroid hormones, T3 and T4, are known to control the development function of many tissues in vertebrates. The paradigm these effects is metamorphosis amphibians. ability create targeted mutations specific genes mouse has allowed generate relevant models which either production thyroid hormone or receptors (TRs) related products defective. These begin provide helpful information understand molecular basis hormones action vivo.
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