The two thyroid hormone receptor genes have opposite effects on estrogen-stimulated sex behaviors
作者： Tammy L Dellovade , John Chan , Bjorn Vennstrom , Douglas Forrest , Donald W Pfaff
DOI: 10.1038/74846
关键词:
摘要: The two genes coding for thyroid hormone receptors (TR) alpha 1 and beta have opposite effects on female sex behaviors. Deletion of TRalpha reduced them, whereas deletion TRbeta actually increased them. These results could not be attributed to altered levels hormones in the blood, general alterations estrogen responsiveness or activity. Instead, they indicate a previously unknown molecular mechanism upon which TR exert influences.
nature.com
sci-hub.se 参考文章(33)
D. Forrest, E. Hanebuth, R. J. Smeyne, N. Everds, C. L. Stewart, J. M. Wehner, T. Curran, Recessive resistance to thyroid hormone in mice lacking thyroid hormone receptor beta: evidence for tissue-specific modulation of receptor function. The EMBO Journal. ,vol. 15, pp. 3006- 3015 ,(1996) , 10.1002/J.1460-2075.1996.TB00664.X
Gustav F. Jirikowski, Jack D. Caldwell, Thomas R. Insel, Cort A. Pedersen, Oxytocin in maternal, sexual, and social behaviors. Oxytocin in Maternal, Sexual, and Social Behaviors, May, 1991, Arlington, VA, US. ,(1992)
I. Izja Lederhendler, Carol Sue Carter, Brian Kirkpatrick, The Integrative Neurobiology of Affiliation ,(1996)
Tammy L. Dellovade, Yuan‐Shan Zhu, Donald W. Pfaff, Thyroid Hormones and Estrogen Affect Oxytocin Gene Expression in Hypothalamic Neurons Journal of Neuroendocrinology. ,vol. 11, pp. 1- 10 ,(1999) , 10.1046/J.1365-2826.1999.00250.X
Catarina Johansson, Björn Vennström, Peter Thorén, Evidence that decreased heart rate in thyroid hormone receptor-α1-deficient mice is an intrinsic defect American Journal of Physiology-regulatory Integrative and Comparative Physiology. ,vol. 275, pp. 40- 646 ,(1998) , 10.1152/AJPREGU.1998.275.2.R640
G. E. Dahl, N. P. Evans, L. A. Thrun, F. J. Karsch, Thyroxine is permissive to seasonal transitions in reproductive neuroendocrine activity in the ewe. Biology of Reproduction. ,vol. 52, pp. 690- 696 ,(1995) , 10.1095/BIOLREPROD52.3.690
Arthur R. Goldsmith, Trevor J. Nicholls, Thyroidectomy prevents the development of photorefractoriness and the associated rise in plasma prolactin in starlings General and Comparative Endocrinology. ,vol. 54, pp. 256- 263 ,(1984) , 10.1016/0016-6480(84)90179-5
H. J. Chen, J. Targovnik, L. McMillan, S. Randall, Age difference in endogenous opiate modulation of short photoperiod-induced testicular regression in golden hamsters Journal of Endocrinology. ,vol. 101, pp. 1- 6 ,(1984) , 10.1677/JOE.0.1010001
I. D. Neumann, H. A. Johnstone, M. Hatzinger, G. Liebsch, M. Shipston, J. A. Russell, R. Landgraf, A. J. Douglas, Attenuated neuroendocrine responses to emotional and physical stressors in pregnant rats involve adenohypophysial changes The Journal of Physiology. ,vol. 508, pp. 289- 300 ,(1998) , 10.1111/J.1469-7793.1998.289BR.X
Charles Sandhofer, Harold L. Schwartz, Cary N. Mariash, Douglas Forrest, Jack H. Oppenheimer, Beta receptor isoforms are not essential for thyroid hormone-dependent acceleration of PCP-2 and myelin basic protein gene expression in the developing brains of neonatal mice. Molecular and Cellular Endocrinology. ,vol. 137, pp. 109- 115 ,(1998) , 10.1016/S0303-7207(98)00005-7