Basic fibroblast growth factor and hematopoiesis.

摘要: Abstract Basic fibroblast growth factor (bFGF or FGF-2) is an angiogenic and pleiotropic involved in the proliferation differentiation of numerous cell types. It expressed mostly tissues mesoderm neuroectoderm origin, plays important role induction, together with transforming factor-beta (TGF-beta). Although hematopoietic cells derive from mesoderm, relatively few studies have addressed bFGF system until recently. appears that produced by bone marrow stromal cells, as well several mature peripheral blood lineages. released stored extra-cellular matrix. FGF-receptors (FGF-Rs) are on nearly every origin tested so far. Growing evidence shows can positively regulate hematopoiesis, acting various cellular targets: early committed progenitors, possibly some cells. synergizes cytokines, antagonizes negative regulatory effects another factor, TGF-beta, thus potentially playing a central hematopoiesis.