Pediatric heart-lung transplantation: intermediate-term results.

摘要: Background : Adult heart-lung transplantation was initiated at Stanford in 1981 and the first pediatric done 1986. Intermediate-term results of University are presented. Methods A retrospective review records all transplantations since 1986 conducted. Results Nineteen were 17 patients. Ages ranged from 2 months to 18 years with a median age 10 years. At time 5 patients infants, 7 children, adolescents. The mean follow-up 29 ± 6.2 (range 1 77, 16) 100% complete. Diagnoses congenital heart disease 13, primary pulmonary hypertension 2, cystic fibrosis, lymphangiectasia, viral pneumonia, obliterative bronchiolitis each. Median wait on list 91 days 707). All had New York Heart Association class III IV symptoms, two receiving ventilator support, six oxygen. Fifteen 19 transplant recipients discharged hospital. 30-day operative mortality rate 5.2% (1 19). actuarial survival 1, 3, for 67%, 51%, 41%, respectively, hospital survivors 82%, 62%, 51%. cause death 4, multisystem organ failure graft coronary artery chronic airway Three required retransplantation, because pneumonia. Two underwent repeat patient single lung transplantation. Rejection diagnosed 73% recipients, has developed 32% recipients. Conclusions Survival approximates that adult procedure Long-term been achieved but factors limiting further improved remain infection bronchiolitis.