Atrial fibrillation: a risk factor for increased mortality--an AVID registry analysis.

摘要: Emerging evidence suggests that atrial fibrillation is not a benign arrhythmia. It associated with increased risk of death. The magnitude association controversial and potential causes remain unknown. Patients in the registry Antiarrhythmics Versus Implantable Defibrillators (AVID) Trial form basis for this report. Baseline variables, particular presence or absence history fibrillation/flutter, were examined relation to survival. Multivariate Cox regression was used adjust differences important baseline co-variables using 27 pre-selected variables. There 3762 subjects who followed an average 773±420 days; 1459 (39%) qualified ventricular 2303 (61%) tachycardia. A fibrillation/flutter present 24.4 percent. many variables between those without fibrillation/flutter. After adjustment differences, remained significant independent predictor mortality, (relative risk=1.20; 95% confidence intervals=1.03−1.40; p=0.020). Antiarrhythmic drug use, other than amiodarone sotalol, also mortality 1.34; intervals 1.07−1.69, p=0.011. Atrial factor patients presenting tachyarrhythmias. This may have been overestimated previous studies could proarrhythmic effects antiarrhythmic drugs sotalol.