Atrial fibrillation is associated with an increased risk for mortality and heart failure progression in patients with asymptomatic and symptomatic left ventricular systolic dysfunction: a retrospective analysis of the SOLVD trials

摘要: Abstract Objective. This study undertook to determine if the presence of atrial fibrillation in patients with asymptomatic and symptomatic left ventricular dysfunction was associated increased mortality and, so, whether increase could be attributed progressive heart failure or arrhythmic death. Background. Atrial is a common condition potential impact hemodynamics progression systolic as well electrophysiologic substrate for arrhythmias. The available data do not conclusively define effect on prognosis failure. Methods. A retrospective analysis Studies Left Ventricular Dysfunction Prevention Treatment Trials conducted that compared those sinus rhythm at baseline risk all-cause mortality, pump-failure death Results. baseline, rhythm, had greater (34% vs. 23%, p Conclusions. an largely explained by These suggest dysfunction.