5,10-Methylenetetrahydrofolate reductase codon 677 and 1298 polymorphisms and colon cancer in African Americans and whites.

摘要: We evaluated polymorphisms in methylenetetrahydrofolate reductase ( MTHFR ), folate intake and alcohol consumption relation to risk of colon cancer a population-based case-control study North Carolina. The included 555 cases (244 African Americans 311 whites) 875 controls (331 544 whites). Total <400 versus ≥400 μg/ day showed weak positive association with among both [adjusted odds ratio (OR) = 1.4, 95% confidence interval (CI) 1.0–2.0] whites (OR 1.6, CI 1.2–2.2). No was observed use alcohol. Compared wild-type genotypes, there no between the low activity codon 677 TT genotype cancer, but 1298 CC inversely associated 0.5, 0.3–0.9). Unlike previous studies, we did not observe strong protective effect low-activity when high. Instead, an increased for participants wild- type genotypes. Adjusted ORs combined effects AA genotypes μg/day were 1.9 (95% 1.1–3.4) 2.5 1.2–5.2) whites. Our results suggest that variation at (within COOH-terminal region) may be more important than (NH2-terminal region), populations where is low, increase cancer.