MTHFR polymorphisms as prognostic factors in sporadic colorectal cancer.
作者： Lucia Procopciuc , Gelu Osian , Liviu Vlad
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摘要: AIM Theoretically, individuals having at least one mutant allele present a modified activity of the MTHFR enzyme and low methylation, DNA synthesis-repair respectively, which could imply higher risk colorectal cancer. The purpose this study was to investigate relations these mutations with clinico-pathological aspects MATERIAL AND METHOD included 69 patients sporadic relative in homozygous normal for C667T A1298C, heterozygous allele, calculated. RESULTS A1298C represent factor cancer an OR (odds ratio) = 2.13 (CI (0.51-8.91)) 3 (CI(0.3-29.58), patients. These are associated more frequent location lesions colon level, OR=2.3 2.15 respectively. incidence mutation stage N0 than N+ (p<0.05), pT2 vs. pT3 as well Dukes stages B D A or C (p<0.05). CONCLUSIONS results obtained support hypothesis increased prevalence gene mutations. develop frequently, they lymph node invasion rarely, often distant metastases.
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