Hypomethylation of DNA: a nongenotoxic mechanism involved in tumor promotion.

摘要: There is an abundant amount of information on the mechanisms action genotoxic chemicals that act as carcinogens and role mutations play in carcinogenesis. However, carcinogenesis more than mutagenesis many are not mutagens. Thus, there a need to consider nongenotoxic may be involved In this paper, we review our working hypothesis hypomethylation DNA epigenetic, mechanism plays tumor promotion by facilitating aberrant gene expression. The utility employing experimental models focus relevant comparisons between sensitive resistant strains mice emphasized. Additionally, aspects methylation rodents humans compared contrasted. We discuss secondary mechanism, expected threshold-exhibiting, conclude describing how facilitate rational approach towards risk assessment when dealing with compounds carcinogenic bioassay.